Yes, definitely. I've been playing guitar for over 20 years and I have a jam-packed schedule.
I work two jobs, mostly seven days a week, and to one of them I drive 4 hours a day. When I'm home I work on personal projects as well as spend time with my wife. Guitar is just one of my personal projects, and I have to fit it in with everything else.
Sometimes I don't feel like doing picking, chromatic, trill, spider, or x-pattern exercises. At those times I'm feeling lazy and I just pick it up and play a few songs. I'm very unstructured in my life and this is no exception.
What always brings me back to a more focused practice is listening to music. The more I listen to skilled guitarists the more inspired I am. I also listen to a lot of podcasts and videos around my work (I'm a marketing manager), and what excites me is what I can imagine from a musical perspective when I consider my other skills and how I can tie them into it.
Basically, I look at everything I'm god at and enjoy doing, and figure out a way to do all of them in one package and get paid for it. I'm a marketer and businessman who is good at writing computer code, working with numbers, playing music, organizing things and motivating people. My wife is a travel agent who is reaching retirement age and wants to run a bed & breakfast.
So one idea I've got is a B&B built around the idea of musical exchange. She can run the facility, I can handle the business end and the music and promotion.
But to do any of that, I've got to master spider exercises, the fingerboard, x-pattern, all permutations, etc.
When I feel motivated and have life goals, and guitar fits in with them, it's easy to practice because I know the end result is better than today and worth the hard work.